REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
β-actin	Sigma	#A5316, RRID:AB_476743
phospho-ERK1/2	Cell Signaling	#9101, RRID:AB_331646
total ERK1/2	Cell Signaling	#9102, RRID:AB_330744
Myc	Millipore	#05–724, RRID:AB_309938
β-klotho	R&D Systems	#AF2619, AB_2131932
Chemicals, Peptides, and Recombinant Proteins
Recombinant Human FGF21	Novo Nordisk	N/A
Human Insulin	Sigma	I9278
Critical Commercial Assays
Human FGF21 ELISA	Biovendor	#RD191108200R
Mouse Leptin ELISA	Millipore	#EZML-82K
Mouse Insulin ELISA	Crystal Chem	#90080
Mouse Adiponectin ELISA	Millipore	#EZMADP-60K
Glucose Autokit	Wako Chemicals	#439-90901
Triglycerides reagent	Thermo Scientific	TR22421
Total Cholesterol reagent	Thermo Scientific	TR13421
Experimental Models: Cell Lines
Primary white adipocytes	This paper	N/A
Experimental Models: Organisms/Strains
Adiponectin KO (B6;129-Adipoqtm1Chan/J)	The Jackson Laboratory	Stock No: 008195
KLBfl/fl (Klbtm1.1Sakl)	Dr. Steven Kliewer, UTSW	N/A
Adiponectin-Cre (B6;FVB-Tg(Adipoq-cre)1Evdr/J)	The Jackson Laboratory	Stock No: 010803
Adiponectin-rtTA	Dr. Philipp Scherer, UTSW	N/A
IRfl/fl (B6.129S4(FVB)-Insr tm1Khn/J)	The Jackson Laboratory	Stock No: 006955
TRE-caFGFR1	Dr. David Ornitz, Washu	N/A
UCP1-Cre mice (B6.FVB-Tg(Ucp1-cre)1Evdr/J)	The Jackson Laboratory	Stock No: 024670
Oligonucleotides
Primers – Klb: 5′-GATGAAGAATTTCCTAAACCAGGTT-3′, 5-AACCAAACACGCGGATTTC-3′	This paper	N/A
Primers – Egr1: 5′-CGAGCGAACAACCCTATGAG-3′, 5′-CATTATTCAGAGCGATGTCAGAAA-3′	This paper	N/A
Primers – cFos: 5′-GGACAGCCTTTCCTACTACCATTCC-3′, 5′-AAAGTTGGCACTAGAGACGGACAGA-3′	This paper	N/A
Primers – Bmp8b: 5′-TCAACACAACCCTCCACATCA-3′, 5′-AGATCGGAGCGTCTGAAGATC-3′	This paper	N/A
Primers – Zbtb16: 5′-CCCAGTTCTCAAAGGAGGATG-3′, 5′-TTCCCACACAGCAGACAGAAG-3′	This paper	N/A
Primers – Fgfr1ca: 5′-TTCATCCTGGTGGTGGCAGC-3′, 5′-GCTCTTCTTGGTGCCGCTCT-3′	This paper	N/A
Primers – U36B4: 5′-CGTCCTCGTTGGAGTGACA-3′, 5′-CGGTGCGTCAGGGATTG-3′	This paper	N/A
Software and Algorithms
Graphpad Prism 7	Graphpad	http://www.graphpad.com/scientific-software/prism/
PMOD version 3.709	PMOD Technologies	http://www.pmod.com/web/
Inveon Research Workplace	Inveon	https://www.healthcare.siemens.com/molecular-imaging/preclinical-imaging/inveon-workplace/inveon-research-workplace
Other
N/A