Table I.
Associations between ABCB1, ALDH1A1 and CD44 expression levels and characteristics of patients with lung adenocarcinoma.
| ABCB1 expression | ALDH1A1 expression | CD44 expression | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables | Total no. (%) | Positive [no. (%)] | Negative [no. (%)] | P-value | Positive [no. (%)] | Negative [no. (%)] | P-value | Positive [no. (%)] | Negative [no. (%)] | P-value |
| No. of cases | 128 (100) | 20 (16) | 108 (84) | 43 (34) | 85 (66) | 67 (52) | 61 (48) | |||
| Age, years | 0.40 | 0.03 | 0.38 | |||||||
| <65 | 47 (37) | 9 (19) | 38 (81) | 10 (21) | 37 (79) | 27 (57) | 20 (43) | |||
| ≥65 | 81 (63) | 11 (14) | 70 (86) | 33 (41) | 48 (59) | 40 (49) | 41 (51) | |||
| Sex | 0.22 | 0.09 | 0.16 | |||||||
| Male | 67 (52) | 13 (19) | 54 (81) | 27 (40) | 40 (60) | 39 (58) | 28 (42) | |||
| Female | 61 (48) | 7 (11) | 54 (89) | 16 (26) | 45 (74) | 28 (46) | 33 (54) | |||
| Tobacco smoking | 0.84 | 0.97 | 0.08 | |||||||
| Yes | 80 (63) | 13 (16) | 67 (84) | 27 (34) | 53 (66) | 47 (59) | 33 (41) | |||
| No | 47 (37) | 7 (15) | 40 (85) | 16 (34) | 31 (66) | 20 (43) | 27 (57) | |||
| Unknown | 1 (1) | 0 (0) | 1 (1) | 0 (0) | 1 (1) | 0 (0) | 1 (1) | |||
| Grade | 0.18 | 0.01 | 0.13 | |||||||
| 1 | 42 (17) | 4 (10) | 38 (90) | 7 (17) | 35 (83) | 26 (62) | 16 (38) | |||
| 2+3 | 86 (83) | 16 (19) | 70 (81) | 36 (42) | 50 (58) | 41 (48) | 45 (52) | |||
| T stage | 0.36 | 0.56 | 0.02 | |||||||
| T1 | 40 (31) | 8 (20) | 32 (80) | 12 (30) | 28 (70) | 27 (68) | 13 (33) | |||
| T2+T3 | 88 (69) | 12 (14) | 76 (86) | 31 (35) | 57 (65) | 40 (45) | 48 (55) | |||
| N stage | 0.51 | 0.81 | 0.36 | |||||||
| N0 | 91 (71) | 13 (14) | 78 (86) | 30 (33) | 61 (67) | 50 (55) | 41 (45) | |||
| N1+N2 | 37 (29) | 7 (19) | 30 (81) | 13 (35) | 24 (65) | 17 (46) | 20 (54) | |||
| Pathological stage | 0.89 | 0.76 | 0.02 | |||||||
| I | 75 (59) | 12 (16) | 63 (84) | 26 (35) | 49 (65) | 46 (61) | 29 (39) | |||
| II+III | 53 (41) | 8 (15) | 45 (85) | 17 (32) | 36 (68) | 21 (40 | 32 (60) | |||
| EGFR mutation status | 0.55 | 0.47 | 0.32 | |||||||
| Positive | 28 (22) | 4 (14) | 24 (86) | 11 (39) | 17 (61) | 17 (61) | 11 (39) | |||
| Negative | 100 (78) | 16 (16) | 84 (84) | 32 (32) | 68 (68) | 50 (50) | 50 (50) | |||
ABCB1, ATP binding cassette subfamily B member 1; ALDH1A1, aldehyde dehydrogenase 1 family member A1; CD, cluster of differentiation; EGFR, epidermal growth factor receptor.