Table III.
Univariate and multivariate Cox proportional hazards models for factors associated with disease-free survival in stage I lung adenocarcinoma patients.
| A, Stage I (n=75) | |||||||
|---|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | ||||||
| Characteristics | Comparison | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age, years | <65 vs. ≥65 | 1.87 | 0.74–4.74 | 0.19 | 1.94 | 0.70–5.38 | 0.20 |
| Sex | Female vs. male | 1.97 | 0.81–4.80 | 0.13 | 2.47 | 0.78–7.88 | 0.13 |
| Tobacco smoking | No vs. yes | 1.62 | 0.60–4.38 | 0.34 | 1.49 | 0.44–5.06 | 0.52 |
| Grade | G1 vs. G2+G3 | 1.36 | 0.54–3.47 | 0.51 | 0.75 | 0.27–2.07 | 0.57 |
| T stage | T1 vs. T2-T4 | 2.70 | 1.00–7.28 | 0.05 | 2.08 | 0.62–7.01 | 0.24 |
| UFT | No vs. yes | 2.54 | 1.06–6.08 | 0.04 | 2.22 | 0.85–5.77 | 0.10 |
| EGFR expression | EGFR− vs. EGFR+ | 1.17 | 0.46–2.96 | 0.75 | 2.03 | 0.63–6.46 | 0.23 |
| ABCB1 status | ABCB1− vs. ABCB1+ | 2.16 | 0.85–5.53 | 0.11 | 1.47 | 0.51–4.25 | 0.47 |
| B, EGFR wild-type (n=56) | |||||||
| Univariate analysis | Multivariate analysis | ||||||
| Characteristics | Comparison | HR | 95% CI | P-value | HR | 95% CI | P-value |
| Age, years | <65 vs. ≥65 | 4.71 | 1.07–20.64 | 0.04 | 4.31 | 0.96–19.40 | 0.06 |
| Sex | Female vs. male | 2.66 | 0.76–9.27 | 0.12 | 1.91 | 0.44–8.31 | 0.39 |
| Tobacco smoking | No vs. yes | 3.30 | 0.75–14.45 | 0.11 | 2.30 | 0.39–13.61 | 0.36 |
| Grade | G1 vs. G2+G3 | 1.23 | 0.43–3.52 | 0.69 | 0.51 | 0.15–1.77 | 0.29 |
| T stage | T1 vs. T2-T4 | 3.08 | 0.88–10.73 | 0.08 | 2.36 | 0.49–11.35 | 0.29 |
| UFT | No vs. yes | 1.58 | 0.61–4.10 | 0.35 | 0.84 | 0.29–2.47 | 0.75 |
| ABCB1 status | ABCB1− vs. ABCB1+ | 4.29 | 1.54–11.92 | 0.01 | 3.49 | 1.03–11.89 | 0.05 |
HR, hazard ratio; CI, confidence interval; EGFR, epidermal growth factor receptor; ABCB1, ATP binding cassette subfamily B member 1; UFT, uracil-tegafur.