Table II.
Univariate analysis of clinicopathologic variables in relation to disease-free and overall survival after elective hepatic resection for hepatocellular carcinoma.
| Disease-free survival | Overall survival | ||||
|---|---|---|---|---|---|
| Factor | N | Hazard ratio (95% CI) | P-value | Hazard ratio (95% CI) | P-value |
| Age (years) | |||||
| ≥65 | 66 | 1.660 (1.123–2.660) | 0.015 | 1.590 (0.7966–3.249) | 0.186 |
| <65 | 78 | Ref | Ref | ||
| Sex | |||||
| Female | 19 | 1.159 (0.5641–2.438) | 0.672 | 1.610 (0.5709–5.571) | 0.322 |
| Male | 125 | Ref | Ref | ||
| Body mass index | |||||
| ≥25 | 43 | 0.836 (0.5344–1.319) | 0.451 | 0.6755 (0.3258–1.493) | 0.355 |
| <25 | 101 | Ref | Ref | ||
| Hepatitis virus | |||||
| HBV | 38 | 0.732 (0.413–1.297) | 0.285 | 0.838 (0.318–2.203) | 0.719 |
| HCV | 55 | 1.170 (0.725–1.888) | 0.521 | 1.294 (0.579–2.893) | 0.530 |
| None | 51 | Ref | Ref | ||
| Child's classification | |||||
| B | 10 | 1.350 (0.5885–3.412) | 0.441 | 2.367 (0.8056–16.04) | 0.095 |
| A | 134 | Ref | Ref | ||
| ICGR15 | |||||
| >10 | 86 | 1.217 (0.8024–1.860) | 0.358 | 1.402 (0.6954–2.795) | 0.351 |
| ≤10 | 58 | Ref | Ref | ||
| Serum α-fetoprotein (ng/ml) | |||||
| >20 | 60 | 1.407 (0.9260–2.210) | 0.015 | 1.878 (0.9483–3.964) | 0.070 |
| ≤20 | 84 | Ref | Ref | ||
| Type of resection | |||||
| Anatomical | 78 | 0.9672 (0.6364–1.468) | 0.874 | 1.755 (0.8796–3.519) | 0.114 |
| Partial | 66 | Ref | Ref | ||
| Duration of operation (min) | |||||
| ≥360 | 77 | 1.198 (0.7917–1.826) | 0.393 | 0.8851 (0.4420–1.768) | 0.729 |
| <360 | 67 | Ref | Ref | ||
| Intraoperative blood loss (g) | |||||
| ≥1,000 | 54 | 1.400 (0.9207–2.223) | 0.114 | 1.712 (0.8590–3.612) | 0.123 |
| <1,000 | 90 | Ref | Ref | ||
| RC transfusion | |||||
| Present | 33 | 1.443 (0.8914–2.549) | 0.127 | 1.657 (0.7659–4.135) | 0.181 |
| Absent | 111 | Ref | Ref | ||
| FFP transfusion | |||||
| Present | 26 | 1.357 (0.7836–2.526) | 0.255 | 1.794 (0.8126–4.952) | 0.131 |
| Absent | 118 | Ref | Ref | ||
| Tumor diameter (cm) | |||||
| >5 | 38 | 1.156 (0.831–1.607) | 0.389 | 2.061 (1.179–3.601) | 0.011 |
| >2, ≤5 | 75 | 0.963 (0.727–1.275) | 0.791 | 1.129 (0.666–1.914) | 0.653 |
| ≤2 | 31 | Ref | Ref | ||
| Tumor number | |||||
| Triple or more | 17 | 2.472 (1.352–4.522) | 0.003 | 2.853 (1.207–6.744) | 0.017 |
| Double | 13 | 1.180 (0.563–2.473) | 0.660 | 0.791 (0.186–3.367) | 0.751 |
| Single | 114 | Ref | Ref | ||
| Portal or venous invasion | |||||
| Positive | 33 | 1.591 (1.010.2.925) | 0.048 | 4.483 (3.279.18.43) | <0.001 |
| Negative | 111 | Ref | Ref | ||
| Glasgow prognostic score | |||||
| 2 | 10 | 2.258 (1.054.4.836) | 0.036 | 7.446 (2.656.20.879) | <0.001 |
| 1 | 58 | 1.503 (0.963.2.346) | 0.073 | 2.530 (1.146.5.585) | 0.022 |
| 0 | 76 | Ref | Ref | ||
HBV, Hepatitis B virus; HCV, hepatitis C virus; ICGR15, retention rate of indocyanine green at 15 min; RC, red cell concentrate; FFP, fresh frozen plasma; GPS, Glasgow prognostic score; CI, confidence interval.