Table 1.
Mendelian randomisation studies of the link between uricaemia and various cardiovascular diseases/risk factors with variants of SLCA9 as instrumental variables
| Author year [ref] | Instrumental variable | No. of participants | Population | Main results |
|---|---|---|---|---|
| McKeigues 2009 [63] | SNP | 1017 | Orkney Islands Scottish | No effect on metabolic syndrome |
| Parsa 2012 [58] | SNP | 516 | Amish | Increase in ambulatory SBP, with low- and high-salt diets |
| Palmer 2013 [62] | SNP | >58,000 >10,000 |
Danes | No effect on BP or ischemic heart disease |
| Testa 2014 [61] | SNP | 755 | Southern Italy | Prediction of CKD progression |
| Mallamaci 2015 [59, 60] | SNP | 449 | Southern Italy | Increase in office SBP and US carotid atherosclerosis features |
BP blood pressure, SBP systolic blood pressure, SNP single nucleotide polymorphism, CKD chronic kidney disease, US ultrasonography