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. 2017 Apr 28;14(1):111–118. doi: 10.3892/ol.2017.6102

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — miR-4530 downregulates VASH1 expression in human breast carcinoma cells. (A) WT and Mut VASH1 mRNA of miR-4530 targeting sequences. Mutated sequences are indicated in bold type. (B) miR-4530 mimics inhibited WT but not Mut VASH1 reporter activity in HEK-293T cells. (C) miR-4530 downregulated the expression of endogenous VASH1 protein in human breast carcinoma cells compared with the empty plasmid control group. (D) miR-4530 significantly downregulated the expression of endogenous VASH1 mRNA in human breast carcinoma cells compared with the empty plasmid control group. WT, wild-type; Mut, mutant; 3′UTR, 3′-untranslated region; VASH1, vasohibin-1; miR, microRNA; ctrl, control. *P<0.05, **P<0.01.