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. 2017 Jul 5;130(13):1570–1577. doi: 10.4103/0366-6999.208235

Figure 1.

Figure 1

Targeting of HIF-1α gene. (a) Targeting strategy to create HIF-1α allele. (b) PCR analysis of DNA isolated from tails of HIF-1α-KO mice showing WT, heterozygous (HIF-1αflox/-), and homozygous genotypes (HIF-1αflox/flox) for the conditional targeted allele. (c) PCR analysis of DNA isolated from tails of HIF-1α-KO mice showing Cre- and Cre+ genotypes. (d) HIF-1α messenger RNA expressions in various tissues of WT and HIF-1α-KO mice. HIF-1α: Hypoxia-inducible factor-1α; WT: Wild-type; PCR: Polymerase chain reaction; KO: Knockout. *P < 0.05.