Table 3.
Top ten upregulated mRNAs in WT and HIF-1α-KO mice
| Genes | RPKM in WT mice | RPKM in KO mice | Fold changes | P |
|---|---|---|---|---|
| JUNB | 165 | 765 | 2.24 | <0.00001 |
| BTG2 | 242 | 617 | 1.82 | <0.00001 |
| SIK1 | 491 | 1105 | 1.77 | <0.00001 |
| MT1 | 361 | 753 | 1.59 | <0.00001 |
| NR4A2 | 51 | 145 | 1.56 | <0.00001 |
| UT2R | 37 | 91 | 1.55 | <0.00001 |
| KLF10 | 559 | 943 | 1.50 | <0.00001 |
| MT2 | 231 | 609 | 1.48 | <0.00001 |
| FOSL2 | 357 | 698 | 1.48 | <0.00001 |
| MIDN | 371 | 575 | 1.42 | 0.00014 |
RPKM: Reads Per Kilobase of exon model per million mapped reads; JUNB: Jun B proto-oncogene; BTG2: B-cell translocation gene 2; SIK1: Salt-inducible kinase 1; MT1: Metallothionein 1; NR4A2: Nuclear receptor subfamily 4, Group A, member 2; UT2R: Urotensin 2 receptor; KLF10: Kruppel-like factor 10; MT2: Metallothionein 2; FOSL2: Fos-like antigen 2; MIDN: Midnolin; WT: Wild type; HIF-1α: Hypoxia-inducible factor-1α; KO: Knockout; mRNA: Messenger RNA.