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AM1241 stimulated β-endorphin release from cultured human keratinocytes (HaCaT) cells. AM630 (1 μM) inhibited the effects of AM1241 (1 μM). AM630 had no effect in the absence of AM1241. Data are expressed as percent of release in medium alone and presented as mean ± SEM. n = 12 per group. *, P < 0.05 compared with medium alone. #, P < 0.05 compared with 1 μM AM1241.
