TABLE II.

Frequency of Clinical Findings in Prader-Labhart-Willi Syndrome Individuals (%)

Clinical features	Overall	[1]a	[2]	[3]	[4]	[5]	[6]	[7]	Present study (N = 39)
Gestation
Reduction or absence of intrauterine fetal activity	77	NGb	54	NG	74	NG	84	NG	86
Breech delivery	33	25	25	NG	40	NG	38	NG	30
Neonatal period and infancy
Low birth weight (< 2.27 kg)	36	12	76c	36c	21	24	20	NG	17
Neonatal feeding difficulty	94	100	91	100	100	60	90	100	100
Hypotonia	100	100	100	100	100	NG	100	100	100
Retarded psychomotor development	98	100	NG	100	100	NG	90	92	100
CNS function and behavior
Mental impairment	99	100	94d	100	97	100	100	100	100
Convulsions	19	NG	12	0	16	39	20	NG	24
Hyperphagia	86	NG	NG	100	NG	NG	71	100	85
Growth
Obesity	93	100	100	100	100	65	100	100	87f
Short stature (< −1 SD)	78	63	100	57	94	50	90	83	71
Facies
Almond-shaped palpebral fissures	55	NG	NG	NG	[9	NG	NG	92	74
Sexual Development
Hypogenitalism	98	88	100	100c	100	NG	100	83	100
Limbs
Small hands and feet	76	NG	100	86	79	NG	100	67	71
Metabolic system
Reduced glucose tolerance	34	NG	NG	93	30	NG	NG	NG	15

^a1, Laurance [1967], N = 8; 2, Dunn [1968], N = 17; 3, Zellweger and Schneider [1968], N = 14; 4, Hall and Smith [1972], N = 32; 5, Mattel et al [1983], N = 20; 6, Bray et al [1983], N = 21; 7, Cassidy et al [1984], N = 12.

^bNG, not given.

^c3,000 g used as cut-off.

^dIQ 70 used as cut-off.

^eMales only.

^fTriceps skinfold >85th percentile.