Table 3.

SAR103168 plasma pharmacokinetics parameters (course 1).

	Plasma SAR103168, mean ± SD (geometric mean) [CV%]
	1.2 mg/m2	1.7 mg/m2	2.4 mg/m2	4.8 mg/m2	9.6 mg/m2	14.4 mg/m2
Day 1	n = 5	n = 4	n = 5	n = 3	n = 5	n = 4
Cmax (ng/mL)	69.4 ± 29.4 (61.9) [42.4]	78.3 ± 15.6 (77.0) [19.9]	140 ± 70.4 (125) [50.2]	204 ± 83.2 (194) [40.7]	259 ± 43.8 (256) [16.9]	533 ± 198 (501) [37.2]
tmax* (h)	0.92 (0.50–7.00)	0.50 (0.50–0.83)	0.92 (0.50–0.92)	0.92 (0.50–0.92)	1.00 (0.67–1.42)	0.88 (0.50–0.92)
AUClast (ng.h/mL)	109 ± 60.1† (96.0) [55.1]	75.5 ± 21.6 (73.4) [28.7]	283 ± 340 (164) [120.3]	217 ± 66.3 (211) [30.6]	744 ± 800 (543) [107.5]	822 ± 265 (784) [32.3]
Day 5	n = 7	n = 4	n = 5	n = 3	n = 5	n = 4
Cmax (ng/mL)	63.9 ± 47.8 (51.9) [74.8]	170 ± 144 (138) [84.8]	350 ± 546 (156) [155.8]	238 ± 81.5 (228) [34.3]	291 ± 76.9 (282) [26.5]	467 ± 255 (420) [54.6]
tmax* (h)	0.92 (0.50–3.95)	0.96 (0.92–1.33)	1.08 (0.92–1.28)	0.92 (0.50–0.92)	0.92 (0.88–1.00)	0.90 (0.50–1.00)
AUClast (ng.h/mL)	45.7 ± 40.2 (31.5) [87.9]	228 ± 171 (176) [74.8]	468 ± 761 (193) [162.7]	577 ± 179 (560) [31.0]	987 ± 1140 (681) [115.5]	992 ± 684 (3.49) [114.3]
T1/2z (h)	NC ± NC (NC) [NC]‡	NC ± NC (NC) [NC]§	4.35 ± 5.13 (2.41) [117.8]¶	NC ± NC (NC) [NC]‡	3.32 ± 2.69 (2.62) [80.9]†	5.46 ± 6.24 (3.49) [114.3]

C_max, peak plasma concentration; t_max, time of peak plasma concentration; AUC_last, area under the curve up to last measurement; t_1/2z, terminal exponential half-life; SD, standard deviation; CV, coefficient of variation; NC, not calculated.

^*Median (min-max).

^†n = 4.

^‡n = 1.

^§n = 0.

^¶n = 2.