Table 1.

Types of Chronic HBV Control and Cure

Inactive State

Sustained, off drug: No inflammation: normal ALT and liver biopsy HBV DNA low or undetectable HBsAg-positive

Functional Cure (Clinical Resolution)

Sustained, off drug: No inflammation: normal ALT and liver biopsy HBsAg loss Anti-HBs gain

Complete Cure (Virologic Cure)

All of the above plus Loss of cccDNA in the liver

ALT, alanine aminotransferase; anti-HBs, antibody to hepatitis B surface antigen; cccDNA, covalently closed circular DNA; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus.