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. 2017 Jun;13(6):348–356.

Table 2.

Strategies to Eradicate Chronic HBV Infection

Virologic Approaches Host Immune Approaches

  • Entry inhibitors

  • Interferons

    • APOBEC3A/3B

  • cccDNA inhibitors

  • TLR-7 agonists

  • Transcription inhibitors

  • Checkpoint inhibitors

    • PD-1/PDL-1 inhibitors

  • RNA silencers

  • IL-7

  • HBV capsid inhibitors

  • Therapeutic vaccines

    • Immune complex vaccines

    • Nasal HBV (NASVAC) vaccines

    • DNA vaccines

    • T-cell vaccines

    • Adenovirus-based vaccines (TG1050)

    • Yeast-based vaccines

  • Polymerase inhibitors

  • Secretion inhibitors

APOBEC3A/3B, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A or 3B; cccDNA, covalently closed circular DNA; HBV, hepatitis B virus; IL, interleukin; PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1; TLR, toll-like receptor.