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. 2017 May 15;31(10):1054–1065. doi: 10.1101/gad.297424.117

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© 2017 Anzo et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 1. — Loss of Eph or Ephrin exhibits ectopic dendritic projection. (A) Schematic diagram of the Drosophila olfactory system. Axons of ORNs expressing the same types of olfactory receptor at the antenna or maxillary palp target one of ∼50 glomeruli in the AL and specifically connect with corresponding dendrites of PNs. PNs are classified into four lineages according to the neuroblasts from which they are produced: anterodorsal PNs (ad-PNs; blue), lateral PNs (l-PNs; red), ventral PNs, and lateroventral PNs. (B,C) Names of the 18 glomeruli (out of ∼50) located at the anterior half of the AL. Each glomerulus is identifiable by its size, shape, and relative position. The glomeruli where dendrites of l-PNs and ad-PNs innervate are colored in red and blue, respectively. (D–I) Green indicates PN neuroblast clones labeled by mCD8-GFP driven by GH146-Gal4-based MARCM. Magenta represents the presynaptic marker Bruchpilot. (D,E) Wild-type neuroblast clones: l-PNs (D; n = 9) and ad-PNs (E; n = 7). (F,G) l-PNs (F; n = 6) and ad-PNs (G; n = 10) of Eph^X652. Ectopic dendrite projections were observed (arrowheads). (H,I) l-PNs (H; n = 4) and ad-PNs (I; n = 7) of ephrin^I95. Ectopic dendrite projections were also observed (arrowheads). Bar, 25 µm.