Table 3.

Factors associated with metachronous advanced neoplasia, training data

	Unadjusteda		Adjustedb
	OR (95 % CI)	p value	OR (95 % CI)	p value
Demographics
Age (per year)	1.04 (1.03–1.05)	<0.001	1.03 (1.02–1.04)	<0.001
BMI	1.01 (0.99–1.03)	0.17
Sex
Female	Ref
Male	1.24 (1.03–1.50)	0.02
Race/ethnicity
White	Ref
African-American	1.00 (0.71–1.42)	0.99
Other	0.88 (0.61–1.28)	0.51
Family history of colorectal cancer
No	Ref
Yes	1.04 (0.86–1.26)	0.68
Unknown	1.07 (0.78–1.47)	0.68
Cigarette smoker
Never	Ref
Former	1.10 (0.92–1.31)	0.31
Current	0.97 (0.75–1.25)	0.80
Personal history of previous polyp
No	Ref		Ref
Yes	1.45 (1.21–1.75)	<0.001	1.50 (1.23–1.84)	0.001
Unknown	0.85 (0.68–1.07)	0.16	0.90 (0.71–1.14)	0.38
Adenoma characteristics
Number (per adenoma)	1.25 (1.19–1.32)	<0.001	1.13 (1.06–1.21)	<0.001
Size (per mm)	1.05 (1.04–1.06)	<0.001	1.03 (1.02–1.04)	<0.001
Location
Distal colorectum	Ref		Ref
Proximal only	1.44 (1.19–1.76)	<0.001	1.41 (1.14–1.74)	0.002
Proximal and distal	2.25 (1.83–2.76)	<0.001	1.51 (1.17–1.95)	0.002
Unknown	1.08 (0.69–1.70)	0.73	0.96 (0.58–1.61)	0.88
Histology
Tubular	Ref		Ref
Tubullovillous or villous	2.11 (1.76–2.54)	<0.001	1.63 (1.32–2.00)	<0.001
Unknown/other	1.31 (1.01–1.71)	0.04	1.09 (0.83–1.45)	0.53
High-grade dysplasia
No	Ref
Yes	1.81 (1.38–2.36)	<0.001
Unknown CPPS	1.23 (0.96–1.58)	0.11
Unknown AFT	0.85 (0.65–1.10)	0.22

^aUnadjusted OR from simple logistic regression model

^bAdjusted OR from the best selected multivariable logistic regression model. Note that the ORs are not available for risk factors that were not selected in the best model. Ref, reference group