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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Liver Transpl. 2017 Jun;23(6):791–803. doi: 10.1002/lt.24770

Figure 2. MSC-EV reduce biochemical markers of hepatic injury during hepatic ischemia reperfusion injury in vivo.

Figure 2

(A) Experimental schema. MSC-EV or vehicle controls (PBS) were administered intravenously 30 minutes prior to induction of hepatic ischemia for 90 minutes, followed by reperfusion for up to 6 hours. (B) Serum biochemical studies 6 hours after reperfusion in mice receiving PBS or MSC-EV (EV) or in sham operated controls. Data are expressed as the mean±SEM (n=6 mice/group). * p<0.05, ** p<0.01, *** p<0.001. (C) Time-course of serum ALT levels in mice during hepatic IRI. Data are expressed as the mean±SEM (n=3–6 mice/group). * p<0.05 or ** p<0.01in EV treated versus PBS controls at the indicated time points after reperfusion.