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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Liver Transpl. 2017 Jun;23(6):791–803. doi: 10.1002/lt.24770

Figure 8. Effect of MSC-EV on CXCL1 mRNA expression in vivo and in vitro.

Figure 8

(A) The time-course of CXCL1 mRNA level in liver of hepatic IRI mice. * p<0.05 *** p<0.001 between EV treated and control groups at the indicated time points. (B) CXCL1 mRNA level in hepatic IRI mice at 6 hours after reperfusion. (C) CXCL1 mRNA was assessed in primary mouse hepatocytes cultured with MSC-EV or PBS (controls) for 6 hrs under normoxia with or without prior exposure to 90 minutes hypoxia. Data represents fold-change of Nlrp12 mRNA with MSC-EV compared with PBS (controls). *** p<0.001. Data are expressed as the mean±SEM (n=3–6 mice/group). N7.5 = normoxia 7.5 hr, H1.5/N6 = 1.5 hr hypoxia followed by 6 hr normoxia