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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2017 Mar 20;323:74–80. doi: 10.1016/j.taap.2017.03.012

Table 2.

Reported Plasma Concentrations of the Tested Tryptophan Metabolites and IDO1 Inhibitors

(Aarsland et al., 2015), (Schwieler et al., 2016), (Wirthgen et al., 2016), (Soliman et al., 2016), (Shi et al., 2016), (Nayak et al., 2015)

Tryptophan Metabolite Steady State Plasma Levels (μM) References
Kynurenine 1.57–3.1 Aarsland et al., 2015; Schwieler et al., 2016
Kynurenic Acid 0.046
Quinolinic Acid 0.306
IDO1 Inhibitor [Cmax] Plasma Levels (μM) References
1-Methyl-L-Tryptophan ~30 (porcine) Wirthgen et al., 2016
1-Methyl-D-Tryptophan ~16 Soliman et al., 2016
INCB024360 ~2 Shi et al., 2016
NLG919 ~40 Nayak et al., 2015
Norharmane ~ no known reference

Cmax, Concentration Maximum