Table 1.
K-ras mutation and the loss of heterozygosity of microsatellitemarkers of colonic Paneth cell metaplasia
K-ras* | D2S123 | D17S250 | D5S346 | Total LOH* | |
PaM | 28.9% | 35.4% | 13.7% | 0% | 40.4% |
(15/52) | (17/48) | (7/51) | (0/52) | (21/52) | |
Normal | 0% | 0% | 0% | 0% | 0% |
(0/8) | (0/8) | (0/8) | (0/8) | (0/8) |
PaM : Colonic Paneth cell metaplasia,
Normal : Normal colonic mucosa, K-ras : K-ras codon 12 mutation,
* : between PaM and Normal, p < 0.01, chi-square test