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. 2017 Jun 12;114(26):E5256–E5265. doi: 10.1073/pnas.1617270114

Fig. 7.

Fig. 7.

Chronic inhibition of interaction between CaMKIIβ and F-actin ameliorates spine abnormalities of Purkinje cells in adult L7-Cre;Itpr1flox/flox mice in vivo. (A) Spine morphology on distal dendrites of Purkinje cells from Itpr1flox/flox;Pcp2-GFP or L7-Cre;Itpr1flox/flox;Pcp2-GFP mice treated with KN-93 or KN-92. Sagittal cerebellar sections were stained with anti-GFP antibody. (Scale bar, 2 μm.) (B) Quantitative analysis of spine density (Left), spine length (Center), and spine head width (Right) of distal dendrites of Purkinje cells. **P < 0.01, ***P < 0.0001, one-way ANOVA with Bonferroni’s test for multiple comparison. White bars: KN-92-treated Itpr1flox/flox;Pcp2-GFP Purkinje cells. Gray bars: KN-93 treated Itpr1flox/flox;Pcp2-GFP Purkinje cells. Black bars: KN-92 treated L7-Cre;Itpr1flox/flox;Pcp2-GFP Purkinje cells. Hatched bars: KN-93 treated L7-Cre;Itpr1flox/flox;Pcp2-GFP Purkinje cells. The numbers of neurons or spines are indicated in each graph.