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. 2017 Jun 12;114(26):6812–6817. doi: 10.1073/pnas.1701002114

Fig. S4.

Fig. S4.

c-IAP1 and c-IAP2 play key roles in the enhanced oncolytic effect induced by SMCs in Huh-7 cells. The effect of birinapant on expression of three classical IAPs in HCT 116 (A) and Huh-7 (B) cells is shown. The effect of siRNAs to c-IAP1 (C), c-IAP2 (D) and XIAP (E) on the protein level of each is shown. (F–H) Huh-7 cells were treated with siRNAs to c-IAP1, c-IAP2, and XIAP; 48 h later, M1 virus (MOI = 1 pfu/cell) was added for another 48 h and relative cell viability was detected. Error bars represent mean ± SD obtained from three independent experiments. B, birinapant; M, mock; NC, negative control; n.s., no significance. *P < 0.05; **P < 0.01; ***P < 0.001.