Fig. S9.

Pan-caspase inhibitors or JNK inhibitor did not abrogate the combined cytotoxicity and viral load. (A) HCT 116 and Huh-7 cells were pretreated with Z-VAD-FMK, Q-VD-Oph, or SP600125 for 2 h, followed by LCL161 (5 μM) plus recombinant M1 (rM1)-GFP (MOI = 1 pfu/cell) virus for another 48 h. Cell viability was detected. (B) HCT 116 cells treated as in A were photographed for cell morphology and GFP staining from M1 virus. Error bars represent mean ± SD obtained from three independent experiments. (Scale bars: 100 μm.)