Fig. 5.

Damage and repair as a function of chromatin states. (A) Cell/naked DNA damage ratio. The effect of genomic states on damage formation is computed by taking the ratio of DNA damage in cell to damage in naked DNA. (B) Relative ratio of total reads normalized by the total input DNA mapping onto each chromatin state. The y axis, which is grouped by chromatin states, shows the time points from 0 to 48 h for CPD and from 0 to 4 h for (6-4)PP. The x axis shows the relative damage ratio. (C) Repair normalized to corresponding damage level. Although some chromatin states have identical names, the 15 states are de novo defined by the combination of histone modifications and CTCF binding. As a result, states 4 and 6 are more enriched around TSS than states 5 and 7.