. 2017 Jul 3;12(7):e0180237. doi: 10.1371/journal.pone.0180237

Table 1. Clinical and laboratory findings and PCR results in 11 case patients with acute Q fever hepatitis.

Case number	Age/ sex	Symptoms	Predisposing factor	AST / ALT / γ-GTP, IU/L	Total bilirubin, mg/dL	IFA titer		Case definition	Treatment	Pathologic findings of liver biopsy	IS1111 PCR result from liver tissues	IS1111 PCR result from blood samples
Case number	Age/ sex	Symptoms	Predisposing factor	AST / ALT / γ-GTP, IU/L	Total bilirubin, mg/dL	Phase 2 IgG	Phase 2 IgM	Case definition	Treatment	Pathologic findings of liver biopsy	IS1111 PCR result from liver tissues	IS1111 PCR result from blood samples
1	70/M	Diarrhea	Gastric cancer, History of tuberculous pleurisy	58/33/74/51	1.9	1:1024	1:152	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Positive^*	Not available
2	62/M	Jaundice	None	49/12/569/57	23	Not done	Not done	Clinical / Pathologic	Doxycycline Rifampin Ciprofloxacin	Periportal fibrosis^†	Positive^*	Not available
3	33/M	Fever	None	80/199/160/115	1.6	1:152	1:256	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Negative	Not available
4	52/M	Fever	History of pulmonary tuberculosis	153/206/213/471	1.4	1:152	<1:16	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Negative	Not available
5	59/M	Fever	History of pulmonary tuberculosis	102/104/103/330	0.9	1:64	1:32	Clinical / Pathologic	Doxycycline	Typical fibrin ring granuloma	Positive^*	Not available
6	58/M	Fever	Diabetes mellitus	139/88/273/229	16.6	1:152	1:64	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Negative	Not available
7	29/M	Fever	None	130/140/70/95	1.1	>1:2048	> 1:2048	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Positive^*	Not available
8	47/M	Fever	Hyperlipidemia	80/92/65/58	0.7	1:128	< 1:16	Clinical / Serologic / Pathologic	Doxycycline	Non-caseating granuloma, portal inflammation	Positive^*	Not available
9	54/M	Fever	Fatty liver	128/75/105/113	4.6	1:1024	1:1024	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Positive^*	Positive^*
10	45/M	Fever	None	118/250/153/185	0.4	< 1:16	1:32	Clinical / Pathologic	Doxycycline	Non-caseating granuloma, portal inflammation	Positive^*	Positive^*
11	37/M	Fever	None	43/65/96/82	2.1	> 1:2048	1:2048	Clinical / Serologic / Pathologic	Doxycycline	Typical fibrin ring granuloma	Positive^*	Negative

* The sequencing data from all positive samples revealed > 99% similarity of Coxiella burnettii isolated LBCE 13265 insertion sequencing IS1111A transposage gene, partial cds (KT965031.1).

† Characteristic fibrin ring granulomas were identified in bone marrow biopsy.