Table 1. Kidney transplant characteristics of the development and validation databases.
| Development Database (n = 664) |
Validation Database (n = 896) |
||
|---|---|---|---|
| Tours | Poitiers | ||
| Total number of transplants | 664 | 706 | 190 |
| Duration of follow-up (years) | 6.4 (± 3.3) | 7.4 (± 2.3) | 7.9 (± 1.2) |
| Functional renal grafts at 10 years post-transplantation | 202 (30.4%) | 171 (24.2%) | 31 (16.3%) |
| Recipient gender (M/F) | 405/259 | NA | NA |
| Recipient age (years) | 49 (± 14) (15–77)* |
NA | NA |
| Donor age (years) | 44 (± 16) | 51 (± 17) | 48 (± 15) |
| HLA A Mismatch | 1.2 (± 0.7) | NA | NA |
| HLA B Mismatch | 1.5 (± 0.6) | NA | NA |
| HLA DR Mismatch | 1.2 (± 0.7) | NA | NA |
| First transplantation | 608 (91.6%) | NA | NA |
| Pretransplant NDSA | 105 (15.8%) | 151 (21.4%) | 34 (17.9%) |
| Serum creatinine at M12 (μM) | 139 (± 71) | 136 (± 49) | 131 (± 40) |
| Proteinuria at M12 (g/L) | 0.18 (± 0.50) | 0.19 (± 0.45) | |
| Proteinuria at M12 (g/24h) | 0.63 (± 1.96) | 0.37 (± 0.80) | |
| Return to dialysis | 69 (10.4%) | 116 (16.4%) | 22 (11.6%) |
| Death with a functional graft (censured data) | 60 (9.0%) | NA | NA |
| de novo NDSA | 142 (21.3%) | NA | NA |
| Median (range) time to onset (years) | 3.02 (0.02–10) | ||
| de novo DSA | 62 (9.3%) | 113 (16%) | 41 (21.6%) |
| Median (range) time to onset (years) | 3.92 (0.02–9.83) | 2.94 (0.79–5.04) | 3.12 (1.95–5.1) |
| Patients with onset of dnDSA in the first year after transplantation | 11 (17.7%) | 35 (31.0%) | 7 (16.7%) |
| First acute rejection episode | 137 (20.6%) | 219 (31%) | 48 (25.3%) |
| Median (range) time to onset (years) | 0.26 (0.01–9.27) | 0.15 (0.04–0.35) | 0.25 (0.03–0.40) |
Data are n (%), mean (± SD) or median (range)
*4 patients under the age of 18 years (3 of them aged 17 years)
DSA = donor-specific anti-HLA antibodies. NDSA = non-donor-specific anti-HLA antibodies. M12 = month 12 post-transplantation. NA Not Appropriate