Table 2. Formula and grading of the 8 noninvasive hepatic reserve markers.

Noninvasive blood tests as liver reserve markers	Formula
ALBI, Grade 1/2/3(<-2.6/-2.6- ≤-1.39 / >-1.39)	(log(bilirubin[μmol/L]) x 0.66)—(albumin[g/L] x 0.085)
APRI, Grade 1/2/3(<0.5/0.5–1.5/ >1.5)	AST (/UNL)/platelet (109/L) × 100
CTP, A/B/C, grade 1/2/3/(5-6/7-9/10-15)	encephalopathy: none = 1, grade 1 or 2 = 2, grade 3 or 4 = 3 ascites: none = 1, mild to moderate = 2, severe = 3 bilirubin (mg/dl): <2 = 1, 2–3 = 2, >3 = 3albumin (g/dl): >3.5 = 1, 2.8–3.5 = 2, < 2.8 = 3PT sec (INR): < 4 (1.7) = 1, 4–6 (1.7–2.3) = 2, > 6 (>2.3) = 3
CDS, Grade 1/2/3(<4/4-7/>7)	platelet count (× 109/L): >340 = 0; 280–339 = 1; 220–279 = 2; 160–219 = 3; 100–159 = 4; 40–99 = 5; <40 = 6
	ALT/AST ratio: >1.7 = 0; 1.2–1.7 = 1; 0.6–1.19 = 2; <0.6 = 3
	INR: <1.1 = 0; 1.1–1.4 = 1; >1.4 = 2; CDS is the sum of the above (possible value 0–11)
FIB-4 index, Grade 1/2/3(<1.45/1.45–3.25/>3.25)	Age × AST/[Platelet × (ALT)1/2]
GUCI, Grade 1/2/3(<0.5/0.5–1.56/>1.56)	AST/TOP NORMAL AST x INR x100/(Platelets x109)
Lok index, Grade 1/2/3(<0.5/0.5–0.8/>0.8)	Lok Index = e(LogOddsLok) / (1 + e(LogOddsLok))Log Odds Lok = (1.26x AST / ALT) + (5.27 x INR)—(0.0089 x Platelets x109)—5.56
MELD, Grade 1/2/3(<10/10-14/>14)	10 x ((0.957 x ln(Creatinine)) + (0.378 x ln(Bilirubin)) + (1.12 x ln(INR))) + 6.43