Fig 1. Post-stroke intraperitoneal-injected C21 results in sustained improvements in neurological function in aged rats.

Behavioral tests were performed at the time points indicated after stroke (black arrow) in rats treated with intraperitoneal injections of saline (n = 8, grey triangles) or C21 (0.03mg/kg, n = 11, black circles), and included the Bederson exam (A), Garcia exam (B), paw adhesive time to touch (C) or removal (D) of paw adhesive, and rotarod performance time (E). Note: n = 3 saline and 4 C21-treated rats for the rotarod test. Data are mean ± SEM; *p<0.05 versus control for respective time points by Mann-Whitney test.