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The AKAP150 complex facilitates PGE2-dependent modulation of TRPV1. The scaffolding protein AKAP controls the phosphorylation state of TRPV1 through its signaling complex containing AC, PKC, calcineurin (CaN), and PKA.
AKAP: A-kinase anchor protein; PGE2: prostaglandin E2; TRPV1: transient receptor potential vanilloid receptor 1; AC: adenylyl cyclase; PKC: protein kinase C; PKA: protein kinase A; cAMP: cyclic adenosine 3′,5′-monophosphate.
