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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Free Radic Biol Med. 2017 Apr 5;108:354–361. doi: 10.1016/j.freeradbiomed.2017.04.001

Figure 3. Clonogenic cell killing in cancer cells by DPEN + CuSO4 is enhanced with Fe sucrose and inhibited with Fe chelation.

Figure 3

Iron chelation using 40 μM DFO for 2 hours prior to 100 μM DPEN + CuSO4 decreases clonogenic killing in MB231 cancer cells (A) and H292 cancer cells (B). In contrast, pretreatment with 250 μM Fe sucrose for 2 hours prior to addition of DPEN + CuSO4 enhances clonogenic cell death (A,B). 15 μM CuSO4 was added to all groups at time of DPEN treatment. *Significantly different than control; p< 0.05. **Significantly different than DPEN. p<0.05; n= 3. Errors represent ± 1 SEM.