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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Genes Brain Behav. 2017 Apr 4;16(6):592–600. doi: 10.1111/gbb.12378

Figure 1. Comparisons between Magel2 knockout mice and wildtype littermates in an open field assay.

Figure 1

(a,c) No differences in the total distance covered or the first 20 minutes of time spent in the center of the chamber, between male wildtype (black bars) and male Magel2 knockout mice (grey bars), were observed in the open field assay. Magel2 knockout male mice did showed significantly reduced time in the center of the chamber, in the last 10 minutes of the assay (unpaired t-test). (b,d) No differences in the total distance covered or the first and last 10 minutes of time spent in the center of the chamber, between female wildtype (black bars) and female Magel2 knockout mice (grey bars), were observed in the open field assay. Magel2 knockout female mice did showed significantly increased time in the center of the chamber, in the second 10 minute bin of the assay (unpaired t-test). (e,f) Male and female Magel2 knockout mice (solid line) showed a decreased horizontal activity when compared to wildtype (dashed line) counterparts, with male Magel2 knockout mice significantly different at 20 and 30 minute time points (2-way ANOVA). (g) When assaying for vertical activity, male Magel2 knockout mice show no difference when compared to wildtype littermates (2-way ANOVA). (h) When assaying for vertical activity, female Magel2 knockout mice show significantly increased vertical activity when compared to wildtype littermates (2-way ANOVA). Total assay time = 30 minutes. n=20 per genotype per sex. *, p<0.05; **, p<0.01; ***, p<0.001; ****, p<0.0001.