Respiratory activity of striatal nonsynaptic mitochondria isolated from 2-month-old FVB/NJ (blue trace) and YAC128 (red trace) mice. In A, representative traces of oxygen consumption by striatal nonsynaptic mitochondria. Where indicated, mitochondria (30μg protein), 300μM ADP, or 60μM 2,4-dinitrophenol (2,4-DNP) were added. The incubation medium was supplemented with the Complex I substrates pyruvate (3 mM) plus malate (1 mM). In B, the pooled group results demonstrating respiratory rates of striatal nonsynaptic mitochondria. Data are mean ± SEM, n = 5.