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. Author manuscript; available in PMC: 2018 Jul 3.
Published in final edited form as: Birth Defects Res. 2017 May 15;109(11):860–865. doi: 10.1002/bdr2.1026

Figure 2.

Figure 2

Incidence and severity of alcohol-induced limb defects. Panels A. and B. portray the incidence of either a left or a right forelimb defect (filled bars) following alcohol exposure on GD 9.25, GD 9.5, or GD 9.75 in Shh+/+ or Shh+/− mice (panel A.) and in Gli2+/+ or Gli2+/− mice (panel B.) The incidence of the most severe left or right forelimb defect is portrayed in colors graded from yellow (least affected, 1) to dark red (most affected, 7). Asterisks denote significant incidence differences between +/+ and +/− mice following Chi square tests (p<0.05). Panels C. and D. portray the average morphology scores (± SEM, vertical lines) for each genotype following alcohol exposure (Panel C.: Shh+/+, yellow circles; Shh+/−, orange circles. Panel D.: Gli2+/+, yellow triangles; Gli2+/−, orange triangles). Asterisks denote significant morphology differences between +/+ and +/− mice following a main effect of genotype (p<0.05).