Table 1.
Clinical features of 765 Italian NAFLD patients stratified by HCC diagnosis.
| Hepatocellular carcinoma | p | ||
|---|---|---|---|
| Yes (n = 132) | No (n = 633) | ||
| Age, years | 67.0 ± 8.8 | 47.5 ± 12.3 | <0.001 |
| Sex, Female | 25 (19) | 163 (26) | 0.25 |
| Obesity, yes | 39 (32) | 202 (32) | 0.99 |
| T2DM, yes | 84 (64) | 124 (20) | <0.001 |
| Severe fibrosis, F3-4 | 111 (84) | 99 (16) | <0.001 |
| PNPLA3, I148M | <0.001 | ||
| I/I | 31 (23) | 231 (36) | |
| I/M | 55 (42) | 283 (45) | |
| M/M | 46 (35) | 120 (19) | |
| TM6SF2, E167K | 0.30 | ||
| E/E | 109 (83) | 538 (85) | |
| E/K | 19 (14) | 88 (14) | |
| K/K | 4 (3) | 7 (1) | |
| MBOAT7, rs641738 C > T | 0.003 | ||
| C/C | 26 (20) | 213 (34) | |
| C/T | 69 (52) | 285 (45) | |
| T/T | 37 (28) | 135 (21) | |
(): % values; T2DM: type 2 diabetes mellitus. Comparisons were performed by logistic regression setting HCC as dependent variable, and the association of genetic variants was analyzed assuming additive models.