Table 3.
Unadjusted | Model 1 | Model 2 | |||||||
---|---|---|---|---|---|---|---|---|---|
OR | 95% c.i. | p | OR | 95% c.i. | p | OR | 95% c.i. | p | |
Age, years | 1.20 | 1.16–1.24 | <0.001 | 1.19 | 1.15–1.23 | <0.001 | 1.16 | 1.11–1.21 | <0.001 |
Sex, Female | 0.57 | 0.41–1.06 | 0.09 | 0.52 | 0.27–0.99 | 0.045 | 0.45 | 0.21–0.91 | 0.026 |
Obesity, yes | 1.11 | 0.75–1.69 | 0.61 | 1.69 | 1.05–2.56 | 0.069 | 2.50 | 1.32–4.76 | 0.008 |
T2DM, yes | 7.18 | 4.81–10.84 | <0.001 | 4.73 | 2.75–8.30 | <0.001 | 3.33 | 1.75–6.44 | <0.001 |
Severe fibrosis, F3-F4 | 28.9 | 17.6–49.5 | <0.001 | NA | NA | NA | 12.5 | 6.36–6.1 | <0.001 |
PNPLA3, n I148M alleles | 1.70 | 1.32–2.21 | <0.001 | 1.61 | 1.12–2.32 | 0.010 | 1.31 | 0.86–2.03 | 0.24 |
TM6SF2, n E167K alleles | 1.27 | 0.82–1.92 | 0.27 | 1.99 | 1.08–3.65 | 0.027 | 2.80 | 1.33–6.10 | 0.008 |
MBOAT7, n T alleles | 2.18 | 1.30–3.63 | 0.003 | 1.81 | 1.24–2.69 | 0.002 | 1.65 | 1.08–2.55 | 0.021 |
OR: odds ratio of HCC, 95% c.i.: 95% confidence interval; T2DM: type 2 diabetes mellitus; n: number of at risk alleles. Comparisons were performed by logistic regression setting HCC as dependent variable, and the association of genetic variants was analyzed assuming additive models. Model 1: adjusted for age, sex, obesity, and T2DM; Model 2: further adjusted for presence of advanced fibrosis; NA: not addressed.