Skip to main content
. 2017 Jul 3;7:4492. doi: 10.1038/s41598-017-04991-0

Table 3.

Independent predictors of HCC in 765 Italian patients with NAFLD.

Unadjusted Model 1 Model 2
OR 95% c.i. p OR 95% c.i. p OR 95% c.i. p
Age, years 1.20 1.16–1.24 <0.001 1.19 1.15–1.23 <0.001 1.16 1.11–1.21 <0.001
Sex, Female 0.57 0.41–1.06 0.09 0.52 0.27–0.99 0.045 0.45 0.21–0.91 0.026
Obesity, yes 1.11 0.75–1.69 0.61 1.69 1.05–2.56 0.069 2.50 1.32–4.76 0.008
T2DM, yes 7.18 4.81–10.84 <0.001 4.73 2.75–8.30 <0.001 3.33 1.75–6.44 <0.001
Severe fibrosis, F3-F4 28.9 17.6–49.5 <0.001 NA NA NA 12.5 6.36–6.1 <0.001
PNPLA3, n I148M alleles 1.70 1.32–2.21 <0.001 1.61 1.12–2.32 0.010 1.31 0.86–2.03 0.24
TM6SF2, n E167K alleles 1.27 0.82–1.92 0.27 1.99 1.08–3.65 0.027 2.80 1.33–6.10 0.008
MBOAT7, n T alleles 2.18 1.30–3.63 0.003 1.81 1.24–2.69 0.002 1.65 1.08–2.55 0.021

OR: odds ratio of HCC, 95% c.i.: 95% confidence interval; T2DM: type 2 diabetes mellitus; n: number of at risk alleles. Comparisons were performed by logistic regression setting HCC as dependent variable, and the association of genetic variants was analyzed assuming additive models. Model 1: adjusted for age, sex, obesity, and T2DM; Model 2: further adjusted for presence of advanced fibrosis; NA: not addressed.