Table 5.
Independent predictors of hepatocellular carcinoma (HCC) in 1121 non-cirrhotic patients with chronic liver diseases associated with hepatic fat accumulation (597 with chronic hepatitis C and 524 with alcoholic liver disease).
| HCC | |||||
|---|---|---|---|---|---|
| No (n = 1096) | Yes (n = 25) | p value | Allelic OR, 95% c.i.* | p value* | |
| PNPLA3 I148M | 558/437/101 (51/40/9) | 8/10/7 (32/40/28) | 0.016 | 1.92, 1.07–3.45 | 0.021 |
| TM6SF2 E167K | 973/122/1 (89/11/0) | 20/5 (80/20) | 0.16 | 1.96, 0.61–5.27 | 0.16 |
| MBOAT7/TMC4 rs641738 C > T | 327/510/259 (30/46/24) | 2/15/8 (8/60/32) | 0.028 | 1.93, 1.07–3.58 | 0.035 |
(): % values; OR: odds ratio; c.i.: confidence interval. Comparisons were performed by logistic regression setting HCC as dependent variable, and the association of genetic variants was analyzed assuming additive models. * Adjusted for age, sex, liver disease etiology, and PNPLA3, TM6SF2 and MBOAT7/TMC4 genetic variants.