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. 2017 Jul 3;7:4554. doi: 10.1038/s41598-017-04813-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Successful deletion of PAX2 in renal tubules derived from iPS cells. (A) Hematoxylin–eosin (HE) staining of kidney tissues induced from wild-type (+/+), heterozygous (+/−), and homozygous (−/−) clones. Arrowheads: glomeruli; arrows: renal tubules. (B) PAX2 (red) and GFP (green) staining of kidney tissues induced from the three genotypes. Rightmost columns: neighbouring sections were stained with markers for renal tubules (E-cadherin: ECAD) and glomerular podocytes (podocalyxin: PODXL). (C) Nephron formation from a mixed colony of iPS cells. Nephron epithelia are composed of PAX2⁺ wild-type and GFP⁺ mutant cells. Scale bars: 50 µm.