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. 2017 Jul 3;7:4538. doi: 10.1038/s41598-017-04731-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The association between rs3217869 genotype and CCND2 expression in prostate tissue samples. Note that the risk A allele of rs3217869 for aggressive prostate cancer was significantly associated with decreased mRNA expression of CCND2. The CCND2 mRNA levels were assessed by Illumina Expression BeadChip-based transcriptional profiling in a collection of 119 human prostate tissue samples^{4, 25}. The CCND2 mRNA expression data in prostate tumor tissues are displayed as the five number distribution (minimum, first quartile, median, third quartile, and maximum) according to rs3217869 genotype The P values were examined by linear regression model and Kruskal-Wallis H test, respectively.