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. 2017 Jul 3;7:4523. doi: 10.1038/s41598-017-04776-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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DNA methylation levels and dynamics at the HOXA gene cluster. (A) Location and organization of the HOXA gene cluster on chromosome 7, with the location of genes and HM27 probes shown. (B) Bar plot showing mean DNA methylation level (beta-value) for each probe located within the HOXA locus, sorted by gene. For first, second and third trimester, n = 18, 10, and 14 were used, respectively. Error bars are standard deviation. (C) Radar plot showing change in methylation (delta-Beta) for each probe within the HOXA cluster in second and third trimester, relative to first trimester placenta. Black line marks 0 (no change in methylation), positive values indicate increase in methylation and negative values indicate decrease in methylation over gestation.