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. 2017 Jul 3;7:4523. doi: 10.1038/s41598-017-04776-5

Figure 8.

Figure 8

Reduction of DLX5, HOXA10 and TLX1 expression in trophoblasts using siRNA leads to lower proliferation and higher expression of differentiation markers siRNA specific for DLX5, HOXA10 and TLX1 were used to knock-down their expression in primary trophoblasts. Expression of DLX5 (A), HOXA10 (D) and TLX1 (G) were reduced by the siRNA. In each case, trophoblast proliferation was reduced (panels B, E, and H). Reduction in DLX5, HOXA10 or TLX1, resulted in increased expression of trophoblast differentiation markers - CGB, ERVW-1 and TP53 (panels C, F, and I). For panels B, E and H, @495 nm = absorbance at 495 nm.