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Pathway analysis of miRNA discovery. The TGFβ canonical pathway was among the top ranked as determined by Ingenuity Pathways Analysis (IPA) software (Ingenuity, Redwood City, CA). Green indicates predicted downregulation of target transcripts by differentially expressed miRNAs; red indicates predicted upregulation. A, urine; B, plasma. Among the altered miRNAs, expression levels of miR-1825, miR-1281, let-7a, and miR-130a are experimentally-validated.
