Table 2.
Effects of helminth infection or exposure on intestinal inflammation
| Model | Detail | Suppression | Reference |
|---|---|---|---|
| Heligmosomoides polygyrus (Nematoda) | |||
| IL-10-deficient colitis | C57BL/6 piroxicam-induced | Histopathology, IFN-γ and IL-12 | (42) |
| RAG transfer model | IL-10−/− T cells + piroxicam | Histopathology | (115) |
| TNBS colitis | C57BL/6 d14 infection, d4 colitis | Histopathology | (156) |
| TNBS colitis | BALB/c d10 infection, d4 colitis | Histopathology, IFN-γ and TNF | (169) |
| RAG transfer model | IL-10−/− T cells + piroxicam | Histopathology, IFN-γ and IL-17 | (15, 65, 66) |
| OVA-specific colitis | OVA-specific T cells and oral OVA | Histopathology, IFN-γ, and IL-17 | (95) |
| DSS colitis | BALB/c mice, up to 18 days | Weight loss and fecal blood | (37) |
| Hymenolepis diminuta (Cestoda) | |||
| DNBS colitis | Infection 8 days before DNBS | Clinical score, histopathology and Myeloperoxidase, IL-10 dependent | (77) |
| DNBS colitis | Infection 8 days before DNBS | Clinical score, histopathology, and myeloperoxidase | (78) |
| DNBS colitis | Infection 8 days before DNBS | Protection IL-25 dependent | (142) |
| Schistosoma japonicum and S. mansoni (Trematoda) | |||
| DSS colitis | Sm Infection 8 wk before DSS | Weight loss, colon shortening, disease activity index | (160) |
| TNBS colitis | Mice exposed to Sm eggs | Histopathology, IFN-γ, and mortality | (41) |
| TNBS colitis | Mice exposed to Sj eggs | Histopathology, IFN-γ | (117) |
| TNBS colitis | Mice exposed to Sj eggs (freeze-thawed) | Histopathology, IFN-γ, and bacterial translocation | (188) |
| TNBS colitis | Rats infected with Sm 7 days before TNBS | Histopathology and myelo-peroxidase | (120) |
| Trichinella spiralis (Nematoda) | |||
| DNBS colitis | Infection 21 days before DNBS | Histopathology, IL-12 and myeloperoxidase | (84) |
| TNBS colitis | Infection 21 days after TNBS | Histopathology, myeloperoxidase and mortality | (189) |
RAG, recombination activating gene; TNBS, trinitrobenzenesulfonic acid; OVA, ovalbumin; DSS, dextran sodium sulfate; DNBS, dinitrobenzene sulfonic acid.