Fig. 1.
Electrophysiologic characteristics of NSC and HSC channels in AT2 cells in primary culture. A: representative traces for NSC channels with a conductance of γ = 21 pS. B: representative traces for HSC channels with a conductance of γ = 6 pS. “C” marks the level with all channels closed. C: current-voltage plots for HSC and NSC. Nonlinear HSC current-voltage relationship and very positive reversal potential are characteristic of ENaC in other cell types and heterologous expression systems. Each point is the mean ± SD of three or more determinations. Fits (solid lines) are to the Goldman-Hodgkin-Katz equation (7, 38, 44).