Table 1. Clinical and laboratory characteristics of the subjects (n=100).
| Characteristic | Total (n=100) | Transient CH (n=65) | Permanent CH (n=35) | P-value |
|---|---|---|---|---|
| Sex, male:female | 53:47 | 35:30 | 18:17 | 0.837a) |
| Birth weight (kg) | 3.2±0.3 | 3.0±0.6 | 3.2±0.4 | 0.505 |
| Gestational age (wk) | 39.3±1.1 | 38.1±2.9 | 39.2±1.7 | 0.265 |
| Age at treatment initiation (day) | 26.7±13.3 | 27.3±14.3 | 25.6±11.3 | 0.550 |
| Free T4 (ng/dL) | 0.74±0.41 | 0.79±0.40 | 0.64±0.43 | 0.075 |
| T3 (ng/dL) | 131.8±40.2 | 135.5±37.7 | 124.4±44.4 | 0.204 |
| TSH (IU/L) | 37.9±26.0 | 30.8±18.8 | 47.1±33.8 | 0.005 |
| Levothyroxine dose (μg/kg) | ||||
| Initial | 9.8±2.9 | 9.7±2.7 | 10.0±3.3 | 0.637 |
| 1 yr | 3.6±1.0 | 3.4±0.8 | 4.1±1.3 | 0.009 |
| 2 yr | 3.1±1.0 | 2.7±0.5 | 3.9±1.3 | <0.001 |
| 3 yr | 2.6±0.9 | 2.3±0.5 | 3.3± 1.2 | <0.001 |
Values are presented as mean±standard deviation.
CH, congenital hypothyroidism; Free T4, free thyroxine; T3, triiodothyronine; TSH, thyroid stimulating hormone.
a)The ratio of sex was not significantly different between 2 groups using the chi-square test.