Table 3. Adjusted MMSE slopes (points/ year) after Alzheimer’s disease diagnosis comparing those who received C-ACEIs and those who received NC-ACEIs.

MMSE slope	Received C-ACEIs	Received NC-ACEIs	MMSE slope difference (MMSE per year)	P for group difference
First MMSE slope 0–9 months	0.72 (0.89 to 0.55)	−0.61 (−0.21 to −1.02)	1.33 (0.25 to 1.41)	0.028
Second MMSE slope 9–36 months	−0.81 (−1.17 to −0.45)	−0.63 (−1.36 to 0.10)	−0.18 (−1.50 to −1.14)	0.531

MMSE, Mini-Mental State Examination; C-ACEIs, centrally acting angiotensin converting enzyme inhibitors; NC-ACEIs, non-centrally acting angiotensin converting enzyme inhibitors.