TABLE 2.

Impact of CETPi administration on vervet monkey lipid profile

	Dalcetrapib			Anacetrapib
	Baseline	90 mg/kg	180 mg/kg	Baseline	3 mg/kg	10 mg/kg
HDL-C, mmol/l	2.29 ± 0.34	1.89 ± 0.33	1.19 ± 0.34a	2.45 ± 0.30	3.78 ± 0.20b	3.89 ± 0.16b
LDL-C, mmol/l	5.98 ± 1.00	7.19 ± 0.90	8.52 ± 1.40a	5.86 ± 0.99	4.93 ± 0.75c	4.33 ± 0.57a
TC, mmol/l	8.81 ± 0.90	9.55 ± 0.77	10.35 ± 1.13c	8.69 ± 0.86	9.58 ± 0.74	9.17 ± 0.60
TG, mmol/l	0.68 ± 0.12	0.55 ± 0.11c	0.88 ± 0.17	0.66 ± 0.08	0.68 ± 0.07	0.74 ± 0.14

Monkeys were fed a diet containing dalcetrapib or anacetrapib and lipid profiles were evaluated biochemically after 14 and 7 days, respectively. Results are shown as the mean ± SEM of seven animals.

^aP < 0.01.

^bP < 0.001.

^cP < 0.05.