Fig. 5.

Cd39 deletion impairs platelet activation. A: In vitro aggregometry response of platelets from ApoE KO and DKO mice fed the standard chow diet following 2.5 μM ADP stimulation. Data are presented as percent of light transmission over the time of incubation. Trace 1 (blue): platelets from ApoE KO mice; trace 2 (black): platelets from DKO mice. Aggregometry response is representative of three ApoE KO and four DKO mice. B: In vivo platelet turnover in ApoE KO and DKO mice fed the standard chow diet. Platelets were labeled and then counted every 24 h for 4 days, as described in the Materials and Methods. Data are presented as mean ± SEM of the percentage of labeled platelets to total platelets over the time of analysis (n = 5 ApoE KO and 4 DKO mice). **P < 0.01, ***P < 0.001.