Fig. 7.

Cd39 deletion results in increased macrophage Abca1-mediated cholesterol efflux. A: Cholesterol efflux to ApoA1 (10 μg/ml) was measured in ApoE KO and DKO BMDMs. Data are expressed as final efflux after subtracting the background (blank) to ApoA1 efflux (n = 2). B: Cholesterol efflux from DKO BMDMs was measured in the presence of ApoA1 or ApoA1 plus apyrase (25 U/ml) (n = 3). C: Cholesterol efflux from ApoE KO BMDMs was measured in the presence of ApoA1 or ApoA1 plus POM1 (26 μM) (n = 3). Blank: control with no acceptor (ApoA-1). All data are presented as mean ± SEM. *P < 0.05. **P < 0.01.