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. 2017 May 29;58(7):1338–1353. doi: 10.1194/jlr.M074229

Fig. 1.

Fig. 1.

Expression of CYP2J2 in cardiomyocytes prevents the development of Ang II-induced cardiac fibrosis. A: Evaluation of collagen deposition by picrosirius red staining, histological analysis of cardiac fibroblast transformation and collagen secretion by immunohistochemical staining of α-SMA and COL I, respectively. B: Quantitation of cardiac fibrosis. C: Quantitation of COLI-positive area. D: Quantitation of α-SMA-positive area. E: Representative immunoblots for CYP2J2, COL I, and α-SMA. F: Quantitation of COL I and α-SMA expression in cardiac tissue. G: Representative immunoblots for nuclear PCNA and MRTF-A in cardiac tissue. H: Quantitation of nuclear PCNA and MRTF-A in cardiac tissue. **P < 0.05 versus WT-saline; &P < 0.05 versus WT-Ang II (n = 10 for each group).