TABLE 4.
Hemodynamic and echocardiography results
| Saline | AngII | |||
| WT | αMHC-CYP2J2-Tr | WT | αMHC-CYP2J2-Tr | |
| Hemodynamic | ||||
| HR (bmp) | 424 ± 6 | 425 ± 5 | 431 ± 5 | 427 ± 5 |
| LVEDP (mmHg) | 4.23 ± 0.04 | 4.19 ± 0.04 | 7.73 ± 0.09a | 5.42 ± 0.08b |
| dp/dt max (mmHg/s) | 5,998 ± 20 | 6,020 ± 18 | 2,793 ± 17a | 4,107 ± 17b |
| dp/dt min (mmHg/s) | 4,632 ± 17 | 4,593 ± 24 | 1,817 ± 23a | 3,106 ± 21b |
| Echocardiography | ||||
| Ejection fraction (%) | 81 ± 0.3 | 80 ± 0.3 | 47 ± 0.4a | 70 ± 0.3b |
| Fraction shortening (%) | 39.7 ± 0.4 | 39.6 ± 0.4 | 26.5 ± 0.3a | 37.4 ± 0.3b |
| LVID (d) (mm) | 3.57 ± 0.04 | 3.58 ± 0.04 | 4.63 ± 0.03a | 3.77 ± 0.02b |
| LVID (s) (mm) | 2.60 ± 0.03 | 2.54 ± 0.04 | 3.39 ± 0.03a | 2.94 ± 0.04b |
dp/dt max, maximal slope of systolic pressure increment; dp/dt min, minimal slope of diastolic pressure decrement; LVID (d), left ventricular internal dimension in diastole; LVID (s), left ventricular internal dimension in systole; LVEDP, left ventricular end diastolic pressure; HR, heart rate; CYP2J2, CYP2J2 transgenic mice (n = 10 for each group).
a
P < 0.05 versus WT-saline.
b
P < 0.05 versus WT-Ang II.