Fig. 1.
FABP4 regulates BLT1R expression and activity. A: BLT1R mRNA expression normalized to TFIIE in stable macrophage cell lines from WT C57BL/6J (black bars) and genetic knockout of FABP4/aP2 (AKO) (gray bars) mice. B: BLT1R and actin protein expression in WT and AKO macrophages. C: Quantification of BLT1R protein levels normalized to actin. D: WT and FABP4/aP2 (AKO) macrophages were treated with 100 nM LTB4 for the indicated times. Following JAK2 immunoprecipitation, immunoblot analysis was conducted using phospho-tyrosine and total JAK2 antibodies. Data were analyzed by Student’s t-test; *P < 0.05.